Novel strategies are required to manufacture customized oral solid dosage forms for\npersonalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets,\nis an attractive strategy, since it allows for the rapid production of solid dosage forms containing\ncustom drug dosages. This study reports on the design and characterization of a biocompatible\nphotocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active\npharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene\nmoieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible\nlight source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry.\nThe engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto\na blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release\nwithin 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid\nproduction of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs.
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